Published Papers

Hanford HA, Wong CA, Kassan H, Cundiff DL, Chandel N, Underwood S, Mitchell CA, Soff GA. Angiostatin4.5-mediated Apoptosis of Vascular Endothelial Cells. Cancer Research 63; 4275-4280, 2003.

Drixler TA, Rinkes IH, Ritchie ED, van Vroonhoven TJ, Gebbink MF, Voest EE. Continuous administration of angiostatin inhibits accelerated growth of colorectal liver metastases after partial hepatectomy. Cancer Research 60(6): 1761-1765, 2000.

Shin SH, Kim JC, Chang SI, Lee H, Chung SI. Recombinant kringle 1-3 of plasminogen inhibits rabbit corneal angiogenesis induced by angiogenin. Cornea 19(2): 212-217, 2000.

Lee H, Kim HK, Lee JH, You WK, Chung SI, Chang SI, Park MH, Hong YK, Joe YA. Disruption of interkringle disulfide bond of plasminogen kringle 1-3 changes the lysine binding capability of kringle 2, but not its antiangiogenic activity. Arch Biochem Biophys 375(2): 359-363, 2000.

Pozzi A, Moberg PE, Miles LA, Wagner S, Soloway P, Gardner HA. Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization. Proc Natl Acad Sci U S A 97(5): 2202-2207, 2000.

Indraccolo S, Minuzzo S, Gola E, Habeler W, Carrozzino F, Noonan D, Albini A, Santi L, Amadori A, Chieco-Bianchi L. Generation of expression plasmids for angiostatin, endostatin and TIMP-2 for cancer gene therapy. Int J Biol Markers 14(4): 251-256, 1999.

Lijnen HR, Van Hoef B, Ugwu F, Collen D, Roelants I. Specific proteolysis of human plasminogen by a 24 kDa endopeptidase from a novel Chryseobacterium Sp. Biochemistry 39(2): 479-488, 2000.

Kim JH, Kim JC, Shin SH, Chang SI, Lee HS, Chung SI. The inhibitory effects of recombinant plasminogen kringle 1-3 on the neovascularization of rabbit cornea induced by angiogenin, bFGF, and VEGF. Exp Mol Med 31(4):203-209, 1999.

Sten-Linder M, Linder C, Strander H, Munck-Wikland E, Wersall P, Linder S, Wiman B. Angiostatin fragments in urine from patients with malignant disease. Anticancer Res 19(4C): 3409-3414, 1999.

Ito H, Rovira II, Bloom ML, Takeda K, Ferrans VJ, Quyyumi AA, Finkel T. Endothelial progenitor cells as putative targets for angiostatin. Cancer Res 59(23):5875-5877, 1999.

Heidtmann HH, Nettelbeck DM, Mingels A, Jager R, Welker HG, Kontermann RE. Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen. Br J Cancer 81(8):1269-1273, 1999.

Pirie-Shepherd SR Role of carbohydrate on angiostatin in the treatment of cancer. J Lab Clin Med 134(6) 553-560, 1999.

Meneses PI, Abrey LE, Hajjar KA, Gultekin SH, Duvoisin RM, Berns KI, Rosenfeld MR. Simplified production of a recombinant human angiostatin derivative that suppresses intracerebral glial tumor growth. Clin Cancer Res 5(11) 3689-3694, 1999.

Ambs S, Dennis S, Fairman J, Wright M, Papkoff J. Inhibition of tumor growth correlates with the expression level of a human angiostatin transgene in transfected B16F10 melanoma cells. Cancer Res 59(22):5773-5777, 1999.

MacDonald NJ, Murad AC, Fogler WE, Lu Y, Sim BK. The tumor-suppressing activity of angiostatin protein resides within kringles 1 to 3. Biochem Biophys Res Commun 264(2) 469-477, 1999.

O'Reilly MS, Wiederschain D, Stetler-Stevenson WG, Folkman J, Moses MA Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance. J Biol Chem 274:41):2956829571, 1999.

Gohongi T, Fukumura D, Boucher Y, Yun CO, Soff GA, Compton C, Todoroki T, Jain RK. Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1. Nat Med 5(10):1203-1208, 1999.

Walter JJ, Sane DC. Angiostatin binds to smooth muscle cells in the coronary artery and inhibits smooth muscle cell proliferation and migration In vitro. Arterioscler Thromb Vasc Biol 19(9):2041-2048, 1999.

Joe YA, Hong YK, Chung DS, Yang YJ, Kang JK, Lee YS, Chang SI, You WK, Lee H, Chung SI Inhibition of human malignant glioma growth in vivo by human recombinant plasminogen kringles 1-3. Int J Cancer 82(5):694-699, 1999.

Chen QR, Kumar D, Stass SA, Mixson AJ. Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice. Cancer Res 59(14):3308-3312, 1999

Cao Y. Therapeutic potentials of angiostatin in the treatment of cancer. Haematologica 84(7):643-650, 1999

Sack RA, Beaton AR, Sathe S. Diurnal variations in angiostatin in human tear fluid: a possible role in prevention of corneal neovascularization. Curr Eye Res 18(3):186-193, 1999.

Liu J, Razani B, Tang S, Terman BI, Ware JA, Lisanti MP. Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1. J Biol Chem 274(22):15781-15785, 1999.

Lu H, Dhanabal M, Volk R, Waterman MJ, Ramchandran R, Knebelmann B, Segal M, Sukhatme VP. Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells. Biochem Biophys Res Commun 258(3):668-673, 1999.

Cao R, Wu HL, Veitonmaki N, Linden P, Farnebo J, Shi GY, Cao Y. Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis. Proc Natl Acad Sci U S A 96(10):5728-5733, 1999.

Stack MS, Gately S, Bafetti LM, Enghild JJ, Soff GA. Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation. Biochem J 340 ( Pt 1):77-84, 1999.

Bergers G, Javaherian K, Lo KM, Folkman J, Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science 284(5415):808-812, 1999

Stathakis P, Lay AJ, Fitzgerald M, Schlieker C, Matthias LJ, Hogg PJ. Angiostatin formation involves disulfide bond reduction and proteolysis in kringle 5 of plasmin. J Biol Chem 274(13):8910-8916, 1999.

Moser TL, Stack MS, Asplin I, Enghild JJ, Hojrup P, Everitt L, Hubchak S, Schnaper HW, Pizzo SV Angiostatin binds ATP synthase on the surface of human endothelial cells. Proc Natl Acad Sci U S A 96(6):2811-2816, 1999.

Redlitz A, Daum G, Sage EH. Angiostatin diminishes activation of the mitogen-activated protein kinases ERK-1 and ERK-2 in human dermal microvascular endothelial cells. J Vasc Res 36(1):28-34, 1999.

Sckell A, Safabakhsh N, Dellian M, Jain RK. Primary tumor size-dependent inhibition of angiogenesis at a secondary site: an intravital microscopic study in mice. Cancer Research 58(24):5866-5869, 1998.

Gorski DH, Mauceri HJ, Salloum RM, Gately S, Hellman S, Beckett MA, Sukhatme VP, Soff GA, Kufe DW, Weichselbaum RR. Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin. Cancer Research 58(24):5686-5689, 1998.

Nguyen JT, Wu P, Clouse ME, Hlatky L, Terwilliger EF. Adeno-associated virus-mediated delivery of antiangiogenic factors as an antitumor strategy. Cancer Research 58(24):5673-5677, 1998.

Cornelius LA, Nehring LC, Harding E, Bolanowski M, Welgus HG, Kobayashi DK, Pierce RA, Shapiro SD. Matrix metalloproteinases generate angiostatin: effects on neovascularization. Journal of Immunology 161(12):6845-6852, 1998.

Hoffman R, Starkey S, Coad J. Wound fluid from venous leg ulcers degrades plasminogen and reduces plasmin generation by keratinocytes. Journal of Investigative Dermatology 111(6):1140-1144, 1998.

Lucas R, Holmgren L, Garcia I, Jimenez B, Mandriota SJ, Borlat F, Sim BK, Wu Z, Grau GE, Shing Y, Soff GA, Bouck N, Pepper MS. Multiple forms of angiostatin induce apoptosis in endothelial cells. Blood 92(12):4730-4741, 1998.

Ji WR, Castellino FJ, Chang Y, Deford ME, Gray H, Villarreal X, Kondri ME, Marti DN, Llinas M, Schaller J, Kramer RA, Trail PA. Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis. FASEB Journal 12(15):1731-1738, 1998.

Lou XJ, Kwan HH, Prionas SD, Yang ZJ, Lawn RM, Fajardo LF. Despite Its Homology to Angiostatin Apolipoprotein(a) Does Not Affect Angiogenesis. Experimental and Molecular Pathology 65(2): 53-63,1998.

Falcone DJ, Khan KMF, Layne T, Fernandes L. Macrophage formation of angiostatin during inflammation. A byproduct of the activation of plasminogen. Journal of Biological Chemistry 273(47):31480-31485, 1998.

Sang QX. Complex role of matrix metalloproteinases in angiogenesis. Cell Research 8(3):171-177, 1998.

Kirsch M, Strasser J, Allende R, Bello L, Zhang J, Black PM. Angiostatin suppresses malignant glioma growth in vivo. Cancer Research 58(20):4654-4659, 1998.

Lee TH, Rhim T, Kim SS. Prothrombin kringle-2 domain has a growth inhibitory activity against basic fibroblast growth factor-stimulated capillary endothelial cells. Journal of Biological Chemistry 273(44):28805-28812, 1998.

Rivas MJG, Arii S, Furutani M, Harada T, Mizumoto M, Nishiyama H, Fujita J, Imamura M. Expression of human macrophage metalloelastase gene in hepatocellular carcinoma: correlation with angiostatin generation and its clinical significance. Hepatology 28(4 Pt 2 Suppl):986-993, 1998.

O'Mahony CA, Albo D, Tuszynski GP, Berger DH. Transforming growth factor-beta 1 inhibits generation of angiostatin by human pancreatic cancer cells. Surgery 124(2):388-393, 1998.

Dong Z, Yoneda J, Kumar R, Fidler IJ. Angiostatin-mediated suppression of cancer metastases by primary neoplasms engineered to produce granulocyte/macrophage colony-stimulating factor. Journal of Experimental Medicine 188(4):755-763, 1998.

Tanaka T, Cao Y, Folkman J, Fine HA. Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA. Cancer Research 58(15):3362-3369, 1998.

O'Mahony CA, Seidel A, Albo D, Chang H, Tuszynski GP, Berger DH. Angiostatin generation by human pancreatic cancer. Journal of Surgical Research 77(1): 55-58,1998.

Mauceri HJ, Hanna NN, Beckett MA, Gorski DH, Staba M-J, Stellato KA, Bigelow K, Heimann R , Gately S, Dhanabal M, Soff GA,Sukhatme VP, Kufe DW, and Weichselbaum RR. Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature 394: 287-291,1998.

Ji WR, Barrientos LG, Llinas M, Gray H, Villarreal X, DeFord ME, Castellino FJ, Kramer RA, Trail PA. Selective inhibition by kringle 5 of human plasminogen on endothelial cell migration, an important process in angiogenesis. Biochemical Biophysical Research Communications, 247(2):414-419, 1998.

Parsons-Wingerter P, Lwai B, Yang MC, Elliott KE, Milaninia A, Redlitz A, Clark JI, Sage EH. A Novel Assay of Angiogenesis in the Quail Chorioallantoic Membrane: Stimulation by bFGF and Inhibition by Angiostatin According to Fractal Dimension and Grid Intersection. Microvascular Research 55(3):201-214, 1998.

Griscelli F, Li H, Bennaceur-Griscelli A, Soria J, Opolon P, Soria C, Perricaudet M, Yeh P, Lu H. Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest. Proceedings of the National Academy of Sciences USA, 95(11):6367-6372, 1998.

Claesson-Welsh L, Welsh M, Ito N, Anand-Apte B, Soker S, Zetter B, O'Reilly M, Folkman J. Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD. Proceedings of the National Academy of Sciences USA, 95(10):5579-5583 1998.

Luo J, Lin J, Paranya G, Bischoff J. Angiostatin upregulates E-selectin in proliferating endothelial cells. Biochemical Biophysical Research Communications, 245(3):906-911 1998.

Barendsz-Janson AF, Griffioen AW, Muller AD, van Dam-Mieras MC, Hillen HF. In vitro tumor angiogenesis assays: plasminogen lysine binding site 1 inhibits in vitro tumor-induced angiogenesis. Journal of Vascular Research, 35(2):109-114 1998.

Lijnen HR, Ugwu F, Bini A, Collen D. Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3). Biochemistry 37(14):4699-4702, 1998

Zetter BR. Angiogenesis and tumor metastasis. Annual Review of Medicine 49:407-424, 1998.

Cao Y, O'Reilly MS, Marshall B, Flynn E, Ji RW, Folkman J. Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases. Journal of Clinical Investigation 101(5):1055-1063, 1998.

Lannutti BJ, Gately ST, Quevedo ME, Soff GA, Paller AS. Human angiostatin inhibits murine hemangioendothelioma tumor growth in vivo. Cancer Research 57(23):5277-5280. 1997.

Saphir A. Angiogenesis: the unifying concept in cancer? J Natl Cancer Inst 89(22):1658-1659, 1997

Kerbel RS. A cancer therapy resistant to resistance. Nature 390(6658):335-336, 1997.

Patterson BC, Sang QA. Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9). Journal of Biological Chemistry 272(46):28823-28825, 1997.

Hu G. Limited proteolysis of angiogenin by elastase is regulated by plasminogen. Journal of Protein Chemistry 16 (7): 669-679, 1997.

Gately S. Twardowski P. Stack MS. Cundiff DL. Grella D. Castellino FJ. Enghild J. Kwaan HC. Lee F. Kramer RA. Volpert O. Bouck N. Soff GA. The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin Proceedings of the National Academy of Sciences USA. 94(20): 10868-10872, 1997.

Cao Y. Chen A. An SSA. Ji RW. Davidson D. Llinas M. Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth. Journal of Biological Chemistry. 272(36):22924-22928, 1997.

Stathakis P. Fitzgerald M. Matthias LJ. Chesterman CN. Hogg PJ. Generation of angiostatin by reduction and proteolysis of plasmin. Catalysis by a plasmin reductase secreted by cultured cells. Journal of Biological Chemistry. 272(33):20641-20645, 1997.

Wu Z. O'Reilly MS. Folkman J. Shing Y. Suppression of tumor growth with recombinant murine angiostatin. Biochemical Biophysical Research Communications. 236(3): 651-654, 1997

Sim PKL. O'Reilly MS. Liang H. Fortier AH. He W. Madsen JW. Lapcevich R. Nacy CA. A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer. Cancer Research. 57(5):1329-1334, 1997.

O'Reilly MS. Boehm T. Shing Y. Fukai N. Vasios G. Lane WS. Flynn E. Birkhead JR. Olsen BR. Folkman J. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.Cell. 88(2):277-85, 1997

Dong Z. Kumar R. Yang X. Fidler IJ. Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma Cell. 88(6):801-810, 1997.

Strohmeyer D. Strohmeyer T. Angiogenesis--principles and significance in urologic tumors. Urologe - Ausgabe A. 35(5):357-62, 1996.

Cao Y. Ji RW. Davidson D. Schaller J. Marti D. Sohndel S. McCance SG. O'Reilly MS. Llinas M. Folkman J. Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells. Journal of Biological Chemistry. 271(46):29461-7, 1996.

Gately S. Twardowski P. Stack MS. Patrick M. Boggio L. Cundiff DL. Schnaper HW. Madison L. Volpert O. Bouck N. Enghild J. Kwaan HC. Soff GA. Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin.Cancer Research. 56(21):4887-90, 1996.

Bicknell R. Harris AL. Mechanisms and therapeutic implications of angiogenesis. Current Opinion in Oncology. 8(1):60-5, 1996.

Jendraschak E. Sage EH. Regulation of angiogenesis by SPARC and angiostatin: implications for tumor cell biology. Seminars in Cancer Biology.7(3):139-46, 1996.

O'Reilly MS. Holmgren L. Chen C. Folkman J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nature Medicine. 2(6):689-92, 1996.

Kost C. Benner K. Stockmann A. Linder D. Preissner KT. Limited plasmin proteolysis of vitronectin. Characterization of the adhesion protein as morpho-regulatory and angiostatin-binding factor. European Journal of Biochemistry. 236(2):682-8, 1996.

Mooser V. Seabra MC. Abedin M. Landschulz KT. Marcovina S. Hobbs HH. Apolipoprotein(a) kringle 4-containing fragments in human urine. Relationship to plasma levels of lipoprotein(a). Journal of Clinical Investigation. 97(3):858-64, 1996.

Battegay EJ. Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects. Journal of Molecular Medicine. 73(7):333-46, 1995.

Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Medicine. 1(1):27-31, 1995.

Bikfalvi A. Significance of angiogenesis in tumour progression and metastasis. European Journal of Cancer. 31A(7-8):1101-4, 1995.

Chen C. Parangi S. Tolentino MJ. Folkman J. A strategy to discover circulating angiogenesis inhibitors generated by human tumors. Cancer Research. 55(19):4230-3, 1995.

Shanahan F. O'Sullivan GC. Angiostatin: candidate for molecule of the year: Gastroenterology. 108(6):1946-8, 1995.

Vile R. Cancer therapy. Less blood means more sanguinity.Current Biology. 5(1):10-3, 1995.

O'Reilly MS. Holmgren L. Shing Y. Chen C. Rosenthal RA. Moses M. Lane WS. Cao Y. Sage EH. Folkman J. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma Cell. 79(2):315-28, 1994.

O'Reilly MS. Holmgren L. Shing Y. Chen C. Rosenthal RA. Cao Y. Moses M. Lane WS. Sage EH. Folkman J. Angiostatin: a circulating endothelial cell inhibitor that suppresses angiogenesis and tumor growth. Cold Spring Harbor Symposia on Quantitative Biology. 59:471-82, 1994.